Journal: Nature communications

Article Title: A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity.

doi: 10.1038/s41467-020-14551-2

Figure Lengend Snippet: Fig. 3 Exome and gene expression analysis. a Whole-exome sequencing showing somatic and loss of heterozygosity variants identified by referencing tumour cells to their matched stromal counterparts. b Summary of mutations in genes associated with HGSOC. c Hierarchical clustering and d principal component analysis of global gene expression profiles, distinguishing stromal and tumour clades, and showing the close relationship of tumour samples from the same patient. 69* is a stromal culture. Symbol colours in a and d serve to distinguish different OCM tumour samples. Source data for panels a and d are provided as a Source Data file.

Article Snippet: Indexed, paired-end, sequencing libraries were then prepared using the Nextera Rapid Capture Expanded Exome enrichment kit (Illumina, Inc.), designed to deliver 62Mb of expertly selected, expanded exonic content.

Techniques: Gene Expression, Sequencing